Scientists from the Mayo Clinic in Minnesota and the Levine Cancer Institute in North Carolina studied 1,475 mesothelioma patients and their response to first or second-line chemotherapy. Of the group, 68% had the most common subtype – epithelioid mesothelioma. Just over 13% had biphasic tumors, and the remaining 9.3% of participants suffered from the most lethal subtype – sarcomatoid mesothelioma. The response patterns to chemotherapy treatment varied over the three types, but overall 21.9% of patients showed a measurable impact on the size of their tumors following the chemotherapy treatment.
Of the group studied, patients with the sarcomatoid subtype of mesothelioma showed a significantly lower response to treatment. Only 13.9% reported a positive impact on tumor size following chemotherapy which was eight percent lower than the overall rate. Though this information may seem discouraging to those suffering from the disease, the study focused only on those who underwent first or second-line chemotherapy. Other mesothelioma treatments options are available, including surgery and radiation, and doctors agree that a multi-modal approach usually produces the best outcomes.
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